This volume is the result of The Fourth Appalachian Conference on Behavioral Neurodynamics, the first three of which were aimed at filling Skinner’s first gap. Taking the series in a new direction, the aim of the fourth and subsequent conferences is to explore the second of the gaps in the behavioral account noted by Skinner. The aim of this conference was to explore the aphorism: The motivation for learning is self organization. In keeping with this aim and in the spirit of previous events, this conference’s mission was to acquaint scientists working in one discipline with the work going on in other disciplines that is relevant to both. As a result, it brought together those who are making advances on the behavioral level — mainly working in the tradition of operant conditioning — and those working with brains — mainly amygdala, hippocampus, and far frontal cortex.